Michael Scofield, a structural engineer, attempts to rob a bank in order to get incarcerated at Fox River State Penitentiary, where his brother Lincoln Burrows, accused of murdering the Vice President's brother, is scheduled to be executed. At Fox River, Michael approaches a number of inmates, all of whom play an important role in his plan to free his brother from the inside. Meanwhile, agents Kellerman and Hale are determined to make sure the execution goes through as planned. Lincoln's son LJ gets into trouble.

Allen EPISODE 2
Michael seeks help of his fellow prison inhabitants to execute his escape plans.

Cell Test EPISODE 3
When Michael reveals his escape plan to Sucre, Sucre chooses to be no part of it, and requests a cell transfer. Michael gets a new cellmate called Haywire.

Cute Poison EPISODE 4
Veronica keeps uncovering new information regarding Lincoln's case and decides she wants to work on the case full-time. When no one wants to help her on the case, Nick Savrinn (an attorney) offers his assistance and the two of them visit Lincoln.

English, Fitz or Percy EPISODE 5
Kellerman and Hale blackmail Warden Pope. Michael finds out he might get out earlier than anticipated. Veronica becomes uncertain of her allies.

Riots, Drills and the Devil (1) EPISODE 6
Michael creates a lockdown by sabotaging the air conditioning in order to execute his breakout plan properly, and unintentionally causes a riot that gets Sara into huge trouble. Meanwhile, an ex-con is blackmailed into seeing to that Lincoln is killed.

Riots, Drills and the Devil (2) EPISODE 7
While the riot intensifies, Abruzzi and Sucre join forces. Michael must decide whether or not to save the life of Dr. Tancredi.

The Old Head EPISODE 8
Michael finds out a storeroom fundamental to his escape plans has been converted into a break room. Veronica and Nick are being threatened, where Nick has a place where they can go which is off the radar of the secret service.

Tweener EPISODE 9
Abruzzi's demotion in the prison hierachy puts the entire escape plan at risk. Michael finds himself in the uneviable position of trying to protect T-Bag's new "fish" and facing the threat of T-Bag exposing the plan to the guards. The inmates dig themselves into a hole.

Sleight of Hand EPISODE 10
Abruzzi struggles to get his crew back to PI. He tries to convince Michael to reveal Fibonacci's whereabouts to Falzone.Agents Kellerman and Hale receive some professional help for their search, as the vice president isn't satisfied about their progress so far.An inmate becomes suspicious of the escapees' work at the break room.Steadman's money trail leads Veronica and Nick to a surprising discovery.

And Then There Were 7 EPISODE 11
Michael gets a visit from his wife, much to everyone's surprise. She brings him what appears to be a credit card, but is in fact something entirely different. Bellick does some research after seeing Michael's wife, whom he thinks looks oddly familiar. Michael learns that his watch has been stolen by a guard, and he must enlist the help of an inmate in order to get it back.In the woods, Veronica, LJ and Nick are threatened by Quinn, who is determined to find out who else knows about the conspiracy.

Odd Man Out EPISODE 12
After learning all the escapees can't make it over the prison wall, the group decides to get rid of T-Bag. T-Bag has a plan of his own that doesn't involve him staying inside. His "insurance", however, is too obvious for Abruzzi, who takes action to undermine it. Sucre gets some good news from Maricruz. Abruzzi's operation goes wrong, and he turns to God for help. He pulls himself together as he takes on T-Bag.

End of the Tunnel EPISODE 13
A bleeding Abruzzi is transported to a hospital. With Lincoln's execution scheduled for the following day, Veronica comes out of hiding to contact him and gains an ally. Kellerman makes the ultimate sacrifice to preserve the conspiracy.Michael looks for a way to get Lincoln out of solitary confinement in time for the escape that evening. The PI crew gets a prolonged stay in the break room they're renovating as they prepare to attempt their escape.

The Rat EPISODE 14
Michael and the other prisoners attempt to return to their cells without being detected. A C.O. becomes suspicious about a broken pipe.At the same time, Veronica and Nick request a judge to postpone Lincoln's execution. Sara requests her dad, the governor, to review Lincoln's case. Michael tries to put a stay in the execution by fiddling with the chair's wirings.

By the Skin and the Teeth EPISODE 15
As Lincoln is about to be executed, he briefly sees his father in the viewing room. A phone call from judge Kessler delays the execution. After reviewing the newly surfaced evidence, the judge orders the exhumation of Steadman's body.Michael creates a new, more dangerous, break-out plan, involving going through the prison yard. An accident puts Michael's new plan in danger.

Brother's Keeper EPISODE 16
Flashbacks shed light on the past actions that led to the incarceration of Lincoln, Sucre, T-Bag and C-Note. Basis of Michael's ingenious break-out plan are revealed. Dr. Tancredi recalls how she ended up in Fox River State Penitentiary.

J-Cat EPISODE 17
Lincoln is worried about Michael's sanity while Michael has trouble remembering some parts of the prison schematics. Sucre has to conceal the hole in the guard's break room. Warden Pope transfers Michael to solitary after he declines his request.

Bluff EPISODE 18
In an effort to recreate the missing piece of the tattoo, Michael gets transferred to the psych ward, seeking the help of Haywire. T-Bag and C-Note have to join forces.

The Key EPISODE 19
Michael must get the key to the infirmary and enlist the help of an old face, while Lincoln learns the identity of his kidnapper and another inmate learns of the escape.

Tonight EPISODE 20
Westmoreland wants Michael to speed up the planned escape, and gets Bellick one step closer to unraveling it. Michael has to decide whether to involve Sara in the breakout plan. Tweener's devotion is put to a test. Veronica finds out that her ally unexpectedly has a connection to an inmate serving time at Fox River.

Go EPISODE 21
Everyone's ready to make their escapes across the high wire. Veronica and Nick realize they may be in over their heads. And Agent Kellerman helps Vice President Reynolds calm down before her debate.

Flight EPISODE 22
As the escape is in progress, Warden Pope and Captain Bellick begin a search to detain the escapees. Michael and co. have to reach the aircraft fast as the police is hot on their heels. Veronica discovers a major piece of evidence that could prove Lincoln's innocence. The Vice President is worried about losing her authority.